MeSH Browser

MeSH Heading: Cytochrome-B(5) Reductase
Tree Number(s): D08.811.682.608.191.237; D12.776.331.186
Unique ID: D042966
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D042966
Annotation: /defic: consider also METHEMOGLOBINEMIA
Scope Note: A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Entry Term(s): Methemoglobin Reductase; NADH Cytochrome B5 Reductase; NADH Methemoglobin Reductase; NADH-Cytochrome B5 Reductase; NADH-Ferrihemoglobin Reductase
Registry Number: EC 1.6.2.2
Related Numbers: 9032-25-1; EC 1.6.2.2
Previous Indexing: Cytochrome Reductases (1975-2003); NADH, NADPH Oxidoreductases (1975-1990); Oxidoreductases (1973-1974)
Public MeSH Note: 2004; CYTOCHROME B(5)REDUCTASE was indexed under CYTOCHROME REDUCTASES 1975-2003 & under OXIDOREDUCTASES 1973-1974; for METHEMOGLOBIN REDUCTASE see METHEMOGLOBIN REDUCTASE 1991-2003, see NADH, NADPH OXIDOREDUCTASES 1975-1990
History Note: 2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - NADH, NADPH Oxidoreductases [D08.811.682.608]
      - Cytochrome Reductases [D08.811.682.608.191]
        
        Cytochrome-B(5) Reductase [D08.811.682.608.191.237]
        
        NADPH-Ferrihemoprotein Reductase [D08.811.682.608.191.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Flavoproteins [D12.776.331]

Cytochrome-B(5) Reductase Preferred

Concept UI: M0073097
Registry Number: EC 1.6.2.2
Related Numbers: 9032-25-1; EC 1.6.2.2
Scope Note: A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Terms: Cytochrome-B(5) Reductase Preferred Term
Term UI T103100
LexicalTag NON
ThesaurusID NLM (2004); NADH-Cytochrome B5 Reductase
Term UI T103099
LexicalTag ABX
ThesaurusID NLM (2004); NADH Cytochrome B5 Reductase
Term UI T474550
Date12/19/2001
LexicalTag ABX
ThesaurusID NLM (2004)

Methemoglobin Reductase Narrower

Cytochrome-B(5) Reductase MeSH Descriptor Data 2024