NLM Logo

DNA Topoisomerases MeSH Descriptor Data 2022


MeSH Heading
DNA Topoisomerases
Tree Number(s)
D08.811.399.403
Unique ID
D026942
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D026942
Scope Note
Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.
Entry Term(s)
Registry Number
EC 5.99.1.-
NLM Classification #
QU 137
Previous Indexing
DNA Topoisomerase (1977-2001)
DNA Topoisomerase (ATP-Hydrolysing) (1979-2001)
Public MeSH Note
2002
History Note
2002
Entry Combination
antagonists & inhibitors:Topoisomerase Inhibitors
Date Established
2002/01/01
Date of Entry
2001/07/25
Revision Date
2010/06/25
DNA Topoisomerases Preferred
page delivered in 0.138s