MeSH Browser

MeSH Supplementary: lorlatinib
Unique ID: C000590786
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C000590786
Entry Term(s): (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile; 7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile; Lorbrena; PF-06463922; PF06463922; loratinib
Registry Numbers: OSP71S83EU; 0
Heading Mapped to: *Aminopyridines; *Lactams; *Pyrazoles
Frequency: 187
Note: inhibits both anaplastic lymphoma kinase and c-ros oncogene 1 (ROS1) protein
Source: J Med Chem. 2014 Jun 12;57(11):4720-44.
Date of Entry: 2014/08/17
Revision Date: 2021/09/09

lorlatinib MeSH Supplementary Concept Data 2025