Famous herbal formula used widely in Chinese herbal medicine for centuries. Originated from Treatise on Cold Damage and Miscellaneous Diseases (200–210, AD), consisting of 10 herbs: Fructus Mume(WM), Radix Angelicae Sinensis(DG), Rhizoma Radix Asari(XX), Radix Aconiti Lateralis Praeparata(FZ), Cortex Phellodendri(HB), Pericarpium Zanthoxyli(HJ), Ramulus Cinnamomi(GZ), Radix Ginseng(RS), Rhizoma Coptidis(HL) and Rhizoma Zingiberis(GJ).