MeSH Browser

MeSH Supplementary: afabicin
Unique ID: C000657127
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C000657127
Entry Term(s): (6-((1E)-3-(Methyl((3-methyl-1-benzofuran-2-yl)methyl)amino)-3-oxo-1-propen-1-yl)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)methyl dihydrogen phosphate; 2-Propenamide, N-methyl-N-((3-methyl-2-benzofuranyl)methyl)-3-(5,6,7,8-tetrahydro-7-oxo-8-((phosphonooxy)methyl)-1,8-naphthyridin-3-yl)-, (2E)-; AFN-1720; Debio 1450; Debio1450
Pharm Action: Anti-Bacterial Agents
Registry Numbers: DMM8663H2R
Heading Mapped to: *Benzofurans; *Naphthyridines
Frequency: 4
Note: antibiotic which targets the staphylococcal enoyl-acyl carrier protein reductase (FabI) and exhibits selective potent antibacterial activity against staphylococcal species, including methicillin-resistant Staphylococcus aureus
Source: Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01669-18.
Date of Entry: 2020/02/11
Revision Date: 2022/11/02

afabicin MeSH Supplementary Concept Data 2025