MeSH Browser

MeSH Supplementary: chlorozotocin
Unique ID: C007028
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C007028
Entry Term(s): 2-(3-(2-chloroethyl)-3-nitrodoureido)-2-deoxy-D-glucopyranose; NSC 178,248; NSC-178248; chlorozotocin, (L)-isomer
Pharm Action: Antineoplastic Agents
Carcinogens
Registry Number: 3053LTY75Z
Related Numbers: 54749-90-5; 69839-80-1
CAS Type 1 Name: 2-((((2-chloroethyl)nitrosoamino)-carbonyl)amino)-2-deoxy-D-glucose
Previous Indexing: ETHYL CHLORIDE (75-78)
Heading Mapped to: Streptozocin / *analogs & derivatives
Frequency: 133
Note: 2-chloroethyl analog of streptozotocin with superior activity against leukemia L1210 and reduced bone marrow toxicity; RN given refers to (D)-isomer; structure
Source: Biochem Pharmacol 26:2331;1977; Cancer 40(5) suppl:2640;1977; Cancer 43(6):2189;1979; Cancer Chemother Pharmacol 1(1):15;1978; Cancer Chemother Pharmacol 1979;3(4):217; Cancer Res 1980;40(1):50; Cancer Res 37(3):783;1977; Cancer Res 37(8):2615;1977; Cancer Treat Rep 1979;63(8):1409; Cancer Treat Rep 60(6):699;1976; Cancer Treat Rep 60(6):801;1976; Cancer Treat Rep 62(1):31;1978; Cancer Treat Rep 62(8):1145;1978; Cancer Treat Rep 63(1):17;1979; Clin Pharmacol Ther 23(6):712;1978; Dokl Akad Nauk SSSR 245(1):260;1979; J Clin Invest 1979;64(4):1103; J Med Assoc Ga 66(9):729;1977; J Med Chem 18(1):104;1975; J Med Chem 22(5):597;1979; NE J Med 301(12):662;1979; Oncology 1980;37(3):177; Toxicology 12(1):3l;1979
Date of Entry: 1975/01/01
Revision Date: 2015/08/18

chlorozotocin Preferred

NSC 178,248 Narrower

chlorozotocin, (L)-isomer Narrower

chlorozotocin MeSH Supplementary Concept Data 2024