MeSH Browser

MeSH Supplementary: 3'-deamino-3'-hydroxydoxorubicin
Unique ID: C042907
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C042907
Entry Term(s): 3'-deamino-4'-epi-3'-hydroxydoxorubin; 3-DHD; hydroxyrubicin
Pharm Action: Topoisomerase II Inhibitors
Registry Number: 73113-90-3
CAS Type 1 Name: 5,12-Naphthacenedione, 10-((2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
Previous Indexing: DOXORUBICIN/*analogs (84-88)
Heading Mapped to: Epirubicin / *analogs & derivatives
Frequency: 11
Note: substitution of the basic amino group at the C-3' of doxorubicin by a hydroxyl group overcomes recognition of the multidrug resistant P-glycoprotein and limits cardiotoxicity; structure given in first source
Source: J Antibiot (Tokyo) 1984;37(8):853
Date of Entry: 1984/11/01
Revision Date: 2013/08/12

3'-deamino-3'-hydroxydoxorubicin MeSH Supplementary Concept Data 2024