catalyzes the cyclization of farnesyl pyrophosphate, probably by intramolecular electrophilic attack by C-1 bearing the pyrophosphate ester on C-11 of the terminal double bond to give a humulyl cation, which undergoes closure to a cyclobutyl intermediate and deprotonation at C-3 methyl to form (-) caryophyllene; MW 57 kDa
