MeSH Browser

MeSH Supplementary: proinsulin endopeptidase II
Unique ID: C061496
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C061496
Entry Term(s): Ca-dependent acidic endoprotease type II; calcium dependent acidic endopeptidase II; insulin secretory granule type II endopeptidase
Registry Numbers: EC 3.4.99.-
Heading Mapped to: *Endopeptidases
Frequency: 10
Note: involved in proteolytic conversion of proinsulin into insulin; cleaves preferentially on the C-terminal side of Lys 64.Arg 65 of proinsulin (C-peptide/A-chain junction); pH optinum 5.5; not inhibited by inhibitors of aspartic proteinases
Source: J Biol Chem 1989;264(31):18335
Date of Entry: 1989/11/27
Revision Date: 1992/12/08

proinsulin endopeptidase II MeSH Supplementary Concept Data 2025