MeSH Browser

MeSH Supplementary: L 685818
Unique ID: C076383
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C076383
Entry Term(s): L 685,818; L-685,818; L-685818
Registry Number: 143839-74-1
CAS Type 1 Name: 15,19-Epoxy-(3H)-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,11,19-trihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,11R*,12S*,14R*,15S*,16R*,18S*,19S*,26aR*))-
Heading Mapped to: Tacrolimus / *analogs & derivatives
Frequency: 15
Note: structure given in first source; the C18-hydroxy, C21-ethyl analog of FK-506; binds to FKBP-12; antagonizes FK-506 and rapamycin
Source: J Exp Med 1992 Sep 1;176(3):751-60
Date of Entry: 1992/09/28
Revision Date: 2001/08/08

L 685818 MeSH Supplementary Concept Data 2024