MeSH Browser

MeSH Supplementary: 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid
Unique ID: C084472
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C084472
Entry Term(s): 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, (3(3R*,5S*,6E),7R*)-isomer; 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7R-(3(3R*,5S*,6E),7R*))-isomer; 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7S-(3(3S*,5R*,6E),7R*))-isomer; biPhMe-TIDHA sodium
Pharm Action: Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registry Number: 153321-50-7
Related Numbers: 153220-25-8; 153220-26-9; 153321-51-8
Heading Mapped to: *Hydroxy Acids; *Indazoles
Frequency: 1
Note: the sodium salt is about 3 times more potent than lovastatin sodium salt; RN given refers to the (3(3S*,5R*,6E),7R*)-isomer; structure in first source
Source: J Med Chem 1993 Nov 12;36(23):3674-85
Date of Entry: 1993/12/27
Revision Date: 2015/08/17

7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid MeSH Supplementary Concept Data 2024