MeSH Browser

MeSH Supplementary: FTI 277
Unique ID: C096856
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C096856
Entry Term(s): FTI-277
Pharm Action: Enzyme Inhibitors
Radiation-Sensitizing Agents
Registry Number: 0
Heading Mapped to: Methionine / *analogs & derivatives
Frequency: 118
Note: a ras CAAX (C - Cys; A - aliphatic amino acid; X - Ser or Met) peptidomimetic; inhibits farnesyltransferase; blocks Ras oncogenic signaling by accumulating Ras/Raf complexes in the cytoplasm; structure given in first source
Source: J Biol Chem 1995 Nov 10;270(45):26802-6
Date of Entry: 1995/12/22
Revision Date: 2001/03/29

FTI 277 MeSH Supplementary Concept Data 2024