NLM Logo

doxorubicin-N-(2-hydroxypropyl)methacrylamide galactosamine conjugate MeSH Supplementary Concept Data 2024


MeSH Supplementary
doxorubicin-N-(2-hydroxypropyl)methacrylamide galactosamine conjugate
Unique ID
C450921
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C450921
Entry Term(s)
PK2 antitumor agent
Registry Number
0
Heading Mapped to
Doxorubicin / *analogs & derivatives
Galactosamine / *analogs & derivatives
*Oligopeptides
*Polymethacrylic Acids
Frequency
1
Note
a polymeric anticancer conjugate composed of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer backbone and pendant doxorubicin (DOX) linked via a Gly-Phe-Leu-Gly peptide spacer, additionally galactose residues are present to facilitate liver targeting; structure in first source
Source
Hum Exp Toxicol 2001 Sep;20(9):461-70
Date of Entry
2002/04/01
Revision Date
2004/02/12
doxorubicin-N-(2-hydroxypropyl)methacrylamide galactosamine conjugate Preferred
page delivered in 0.005s