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N(4)-(2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide MeSH Supplementary Concept Data 2024


MeSH Supplementary
N(4)-(2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide
Unique ID
C455823
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C455823
Entry Term(s)
(2S,3R)-N(4)-((S)-2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide
N(4)-DMHHMPSucc
PKF242-484
Pharm Action
Matrix Metalloproteinase Inhibitors
Registry Number
0
Heading Mapped to
*Hydroxamic Acids
Frequency
8
Note
inhibits both TNF-alpha converting enzyme and matrix metalloproteinases; structure in first source
Source
J Med Chem 2002 May 23;45(11):2289-93
Indexing Information
Metalloendopeptidases
Date of Entry
2002/06/05
Revision Date
2013/08/15
N(4)-(2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide Preferred
(2S,3R)-N(4)-((S)-2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide Narrower
PKF242-484 Narrower
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