MeSH Browser

MeSH Supplementary: ETV6-PDGFRB fusion protein, human
Unique ID: C464679
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C464679
Entry Term(s): ETV6-PDGFRB protein, human
Registry Numbers: 0
Heading Mapped to: *Oncogene Proteins, Fusion; *Receptor, Platelet-Derived Growth Factor beta; *ETS Translocation Variant 6 Protein
Frequency: 11
Note: a small proportion of patients with chronic myeloproliferative diseases have constitutive activation of the gene for platelet-derived growth factor receptor beta (PDGFRB), which encodes a receptor tyrosine kinase. The gene is located on chromosome 5q33, and the activation is usually caused by a t(5;12)(q33;p13) translocation associated with an ETV6-PDGFRB fusion gene; has been sequenced
Source: N Engl J Med 2002 Aug 15;347(7):481-7
Indexing Information: Receptor, Platelet-Derived Growth Factor beta
Date of Entry: 2002/09/03
Revision Date: 2023/08/24

ETV6-PDGFRB fusion protein, human MeSH Supplementary Concept Data 2025