MeSH Browser

MeSH Supplementary: inv(16) fusion protein, human
Unique ID: C471254
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C471254
Entry Term(s): inversion (16) fusion protein, human
Registry Numbers: 0
Heading Mapped to: *Oncogene Proteins, Fusion
Frequency: 22
Note: associates with corepressors via a smooth muscle myosin heavy-chain domain; inversion(16) is one of the most frequent chromosomal translocations found in acute myeloid leukemia (AML), occurring in over 8% of AML cases; this translocation results in a protein product that fuses the first 165 amino acids of core binding factor beta to the coiled-coil region of a smooth muscle myosin heavy chain (CBFbeta/SMMHC)
Source: Mol Cell Biol 2003 Jan;23(2):607-19
Date of Entry: 2003/02/20
Revision Date: 2005/10/25

inv(16) fusion protein, human MeSH Supplementary Concept Data 2025