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TTL-ETV6 fusion protein, human MeSH Supplementary Concept Data 2025


MeSH Supplementary
TTL-ETV6 fusion protein, human
Unique ID
C475279
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C475279
Entry Term(s)
ETV6-TTL fusion protein, human
ETV6-TTL protein, human
TTL-ETV6 protein, human
Registry Numbers
0
Heading Mapped to
*Oncogene Proteins, Fusion
*ETS Translocation Variant 6 Protein
Frequency
1
Note
a fusion gene in acute lymphoblastic leukemia & involved in leukemogenesis; In leukemic cells both reciprocal fusion transcripts, ETV6/TTL and TTL/ETV6, were expressed; the predominant fusion transcript, TTL/ETV6 encodes a predicted 530 aa fusion protein containing 89 aa of the N-terminal TTL fusing to the helix-loop-helix domain and ETS-binding domain of ETV6
Source
Leukemia 2003 Jun;17(6):1112-20
Date of Entry
2003/07/07
Revision Date
2023/08/24
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