MeSH Browser

MeSH Supplementary: CTX-M-27, E coli
Unique ID: C477098
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C477098
Registry Numbers: EC 3.5.2.-
Heading Mapped to: *beta-Lactamases; *Escherichia coli Proteins
Frequency: 21
Note: CTX-M-27 showed that residue Gly-240 decreased Km for ceftazidime (205 versus 940 microM), but decreased hydrolytic activity against good substrates, such as cefotaxime (kcat, 113 versus 415 s-1), probably owing to the alteration of beta3 strand positioning during the catalytic process.
Source: J Antimicrob Chemother. 2003 Jul;52(1):29-35
Date of Entry: 2003/09/12
Revision Date: 2004/02/18

CTX-M-27, E coli MeSH Supplementary Concept Data 2025