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CTX-M-27, E coli MeSH Supplementary Concept Data 2025


MeSH Supplementary
CTX-M-27, E coli
Unique ID
C477098
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C477098
Registry Numbers
EC 3.5.2.-
Heading Mapped to
*beta-Lactamases
*Escherichia coli Proteins
Frequency
21
Note
CTX-M-27 showed that residue Gly-240 decreased Km for ceftazidime (205 versus 940 microM), but decreased hydrolytic activity against good substrates, such as cefotaxime (kcat, 113 versus 415 s-1), probably owing to the alteration of beta3 strand positioning during the catalytic process.
Source
J Antimicrob Chemother. 2003 Jul;52(1):29-35
Date of Entry
2003/09/12
Revision Date
2004/02/18
CTX-M-27, E coli Preferred
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