MeSH Browser

MeSH Supplementary: aplaviroc
Unique ID: C499671
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C499671
Entry Term(s): 4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride; GW873140; benzoic acid, 4-(4-(((3R)-1-butyl-3-((R)-cyclohexylhydroxymethyl)-2,5-dioxo-1,4,9- triazaspiro(55)undec-9-yl)methyl)phenoxy)-; rac-4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid
Pharm Action: HIV Fusion Inhibitors
Registry Numbers: 98B425P30V; 0
Heading Mapped to: *Benzoates; *Piperazines; *Spiro Compounds; *Diketopiperazines
Frequency: 30
Note: a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1; structure in first source
Source: Mol Pharmacol 2005 Apr;67(4):1268-82
Date of Entry: 2005/04/18
Revision Date: 2020/11/24

aplaviroc MeSH Supplementary Concept Data 2025