MeSH Browser

MeSH Supplementary: platensimycin
Unique ID: C510909
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C510909
Pharm Action: Anti-Infective Agents
Fatty Acid Synthesis Inhibitors
Registry Number: Q3DQ78KOFY
CAS Type 1 Name: benzoic acid, 3-((3-((1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl)-1-oxopropyl)amino)-2,4-dihydroxy-
Previous Indexing: *AMINOGLYCOSIDES (2006)
Heading Mapped to: *Adamantane; *Anilides; *Aminobenzoates
Frequency: 109
Note: has antidiabetic and antisteatotic activities; a pentacyclic ketolide (structurally similar to adamantane) connected by an amide bond to 3-amino-2,4-dihydroxybenzoic acid; inhibits cellular lipid biosynthesis; discovered while screening compounds from Streptomyces platensis bacteria in a South African soil sample with S. aureus bacteria deficient in FabF protein; structure in first source
Source: Nature. 2006 May 18;441(7091):358-61
Indexing Information: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase
Date of Entry: 2006/06/13
Revision Date: 2017/07/20

platensimycin MeSH Supplementary Concept Data 2024