Small round white spots (drusen) that appear at the posterior pole of the eye, including the areas of the MACULA LUTEA and OPTIC DISK, in early adulthood and progress to form a mosaic or honeycomb pattern coincident with deterioration of vision. It is caused by mutations in the EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) protein. OMIM: 126600
