MeSH Browser

MeSH Supplementary: Thiopurine S methyltranferase deficiency
Unique ID: C536512
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C536512
Entry Term(s): 6 alpha mercaptopurine sensitivity; TPMT deficiency; Thiopurine S-Methyltransferase Deficiency; Thiopurine methyltransferase deficiency; Thiopurines, poor metabolism of
Registry Number: 0
Heading Mapped to: *Drug Hypersensitivity; *Purine-Pyrimidine Metabolism, Inborn Errors
Frequency: 32
Note: A hereditary autosomal recessive condition that results in an increased sensitivity to 6-MERCAPTOPURINE due to mutations in thiopurine methyltransferase (TPMT gene) causing decreased enzyme activity. OMIM: 187680
Source: Clin Pharm Ther 1989; 46:149
Date of Entry: 2010/08/25
Revision Date: 2015/11/10

Thiopurine S methyltranferase deficiency MeSH Supplementary Concept Data 2024