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Chromosome 13 ring MeSH Supplementary Concept Data 2025
Ring chromosome 13 arises when breaks occur at both ends of the chromosome, forming a circular structure. Affected individuals may experience delayed growth and short stature, have MICROCEPHALY; characteristic facial anomalies (FACIES); abnormal skin pigmentation, and intellectual disability. The severity of symptoms depends on the region of the chromosome where the break occurs and which genes are involved.