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ivacaftor MeSH Supplementary Concept Data 2022


MeSH Supplementary
ivacaftor
Unique ID
C545203
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C545203
Entry Term(s)
3-quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-
Kalydeco
N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
VX-770
Pharm Action
Chloride Channel Agonists
Registry Number
1Y740ILL1Z
Heading Mapped to
*Aminophenols
*Quinolones
Frequency
533
Note
a CFTR potentiator; structure in first source
Source
Proc Natl Acad Sci U S A 2009 Nov 3;106(44):18825-30
Indexing Information
Cystic Fibrosis Transmembrane Conductance Regulator
Date of Entry
2009/11/30
Revision Date
2016/10/31
ivacaftor Preferred
VX-770 Narrower
Kalydeco Narrower
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