A hereditary autosomal dominant disorder that shows some similarities to NEUROFIBROMATOSIS 1 (OMIM: 162200) but is less severe. Affected individuals usually have multiple cafe-au-lait spots, sometimes associated with skin fold freckling, variable dysmorphic features such as HYPERTELORISM or MACROCEPHALY; LIPOMAS, and mild LEARNING DISORDERS or ATTENTION DEFICIT DISORDER. It is not associated with neurofibromas, optic gliomas, Lisch nodules, or tumor predisposition. Mutations in the SPRED1 gene have been identified. OMIM: 611431
