A group of herditary myopathies that may be autosomal dominant or recessive. They are caused by mutations in different genes but are morphologically homogeneous. Morphologic changes in skeletal muscle result from disintegration of the sarcomeric Z disc and the MYOFIBRILS, followed by abnormal ectopic accumulation of multiple proteins involved in the structure of the Z disc, including DESMIN; ALPHA-B-CRYSTALLIN; DYSTROPHIN; and myotilin (OMIM: 604103). OMIM: 601419
