MeSH Browser

MeSH Heading: Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase
Tree Number(s): D08.811.913.696.445.246
Unique ID: D000099235
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099235
Scope Note: A nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP in mammals. This activates the STING1 PROTEIN through the CGAS-STING SIGNALING PATHWAY, which triggers the production of INTERFERON TYPE I and other CYTOKINES.
Entry Term(s): Cyclic GMP-AMP Synthase; cGAS Protein
Registry Numbers: EC 2.7.7.86
Previous Indexing: Nucleotidyltransferases (2013-2025)
Public MeSH Note: 2026
History Note: 2026
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Nucleotidyltransferases [D08.811.913.696.445]
        
        mRNA Guanylyltransferases [D08.811.913.696.445.018]
        
        N-Acylneuraminate Cytidylyltransferase [D08.811.913.696.445.035]
        
        Choline-Phosphate Cytidylyltransferase [D08.811.913.696.445.184]
        
        Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase [D08.811.913.696.445.246]
        
        DNA Nucleotidyltransferases [D08.811.913.696.445.308]
        
        Glucose-1-Phosphate Adenylyltransferase [D08.811.913.696.445.400]
        
        Nicotinamide-Nucleotide Adenylyltransferase [D08.811.913.696.445.600]
        
        2',5'-Oligoadenylate Synthetase [D08.811.913.696.445.625]
        
        Polynucleotide Adenylyltransferase [D08.811.913.696.445.650]
        
        Rec A Recombinases [D08.811.913.696.445.692]
        
        RNA Nucleotidyltransferases [D08.811.913.696.445.735]
        
        Sulfate Adenylyltransferase [D08.811.913.696.445.800]
        
        Transposases [D08.811.913.696.445.825]
        
        Transposon Resolvases [D08.811.913.696.445.837]
        
        UDPglucose-Hexose-1-Phosphate Uridylyltransferase [D08.811.913.696.445.850]
        
        UTP-Glucose-1-Phosphate Uridylyltransferase [D08.811.913.696.445.875]
        
        UTP-Hexose-1-Phosphate Uridylyltransferase [D08.811.913.696.445.900]
        
        VDJ Recombinases [D08.811.913.696.445.950]

Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Preferred

Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase MeSH Descriptor Data 2026