MeSH Browser

MeSH Heading: Hydroxyacylglutathione Hydrolase
Tree Number(s): D08.811.277.352.897.544
Unique ID: D000099301
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099301
Scope Note: A thiolesterase that catalyzes the production of GLUTATHIONE and D-LACTIC ACID from the hydrolysis of S-D-lactoyl-glutathione. In vertebrates, only one gene that encodes hydroxyacylglutathione hydrolase is known to occur. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of this enzyme.
Entry Term(s): Acetoacetylglutathione Hydrolase; Glo2 Hydrolase Enzyme; Glyoxalase II; HAGH Protein; Hydroxyacyl Glutathione Hydrolase
Registry Numbers: 0
Public MeSH Note: 2026; HYDROXYACYLGLUTATHIONE HYDROLASE was indexed under THIOLESTER HYDROLASES 1981-2025, under GLUTATHIONE/analogs 1977-1980, and under GLUTATHIONE 1973-1977
History Note: 2026 (1973)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000769183
Registry Numbers: 0
Scope Note: A thiolesterase that catalyzes the production of GLUTATHIONE and D-LACTIC ACID from the hydrolysis of S-D-lactoyl-glutathione. In vertebrates, only one gene that encodes hydroxyacylglutathione hydrolase is known to occur. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of this enzyme.
Terms: Hydroxyacylglutathione Hydrolase Preferred Term
Term UI T001149097
Date06/18/2025
LexicalTag NON
ThesaurusID NLM (1973); Acetoacetylglutathione Hydrolase
Term UI T001149098
Date06/18/2025
LexicalTag NON
ThesaurusID NLM (1973); Glo2 Hydrolase Enzyme
Term UI T001149099
Date06/18/2025
LexicalTag ABX
ThesaurusID NLM (2017); Glyoxalase II
Term UI T001149100
Date06/18/2025
LexicalTag NON
ThesaurusID NLM (1973); HAGH Protein
Term UI T001149096
Date06/18/2025
LexicalTag ABX
ThesaurusID NLM (2026); Hydroxyacyl Glutathione Hydrolase
Term UI T001149105
Date06/18/2025
LexicalTag NON
ThesaurusID NLM (2026)

Hydroxyacylglutathione Hydrolase MeSH Descriptor Data 2026