MeSH Browser

MeSH Heading: Antibody-Dependent Cell Cytotoxicity
Tree Number(s): G12.287.070
Unique ID: D000920
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000920
Scope Note: The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Entry Version: ANTIBODY DEPENDENT CELL CYTOTOX
Entry Term(s): ADCC; Cell Cytoxicity, Antibody-Dependent; Cytotoxicity, Antibody-Dependent Cell
NLM Classification #: QW 568
Previous Indexing: Cytotoxicity Tests, Immunologic (1971-1977); Immunity, Cellular (1970-1977); Lymphocytes (1966-1977)
Public MeSH Note: 78
History Note: 78
Date Established: 1978/01/01
Date of Entry: 1977/05/13
Revision Date: 2016/06/02

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0001370
Scope Note: The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Terms: Antibody-Dependent Cell Cytotoxicity Preferred Term
Term UI T002714
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Cell Cytoxicity, Antibody-Dependent
Term UI T002716
Date05/21/1991
LexicalTag NON
ThesaurusID NLM (1992); ADCC
Term UI T002715
Date09/29/1993
LexicalTag ABB
ThesaurusID NLM (1995); Cytotoxicity, Antibody-Dependent Cell
Term UI T002713
Date05/13/1977
LexicalTag NON
ThesaurusID UNK (19XX)

Antibody-Dependent Cell Cytotoxicity MeSH Descriptor Data 2024