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Antibody-Dependent Cell Cytotoxicity MeSH Descriptor Data 2022


MeSH Heading
Antibody-Dependent Cell Cytotoxicity
Tree Number(s)
G12.287.070
Unique ID
D000920
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000920
Scope Note
The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Entry Version
ANTIBODY DEPENDENT CELL CYTOTOX
Entry Term(s)
ADCC
Cell Cytoxicity, Antibody-Dependent
Cytotoxicity, Antibody-Dependent Cell
NLM Classification #
QW 568
Previous Indexing
Cytotoxicity Tests, Immunologic (1971-1977)
Immunity, Cellular (1970-1977)
Lymphocytes (1966-1977)
Public MeSH Note
78
History Note
78
Date Established
1978/01/01
Date of Entry
1977/05/13
Revision Date
2016/06/02
Antibody-Dependent Cell Cytotoxicity Preferred
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