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S100 proteins that aggregate KERATINS. Filaggrin precursor proteins are localized in keratohyalin granules and processed into individual functional filaggrin molecules during terminal epidermis differentiation. Mutations in fillagrins are associated with ICHTHYOSIS VULGARIS.
Entry Term(s)
Filaggrin
Filaggrin Protein
Profilaggrin
Stratum Corneum Basic Protein
Stratum Corneum Basic Protein Precursor
Registry Numbers
0
Previous Indexing
Intermediate Filament Proteins (1982-2021)
Public MeSH Note
2022; FILAGRIN was indexed under INTERMEDIATE FILAMENT PROTEINS 1984-2021; and under PROTEINS 1981-1983
S100 proteins that aggregate KERATINS. Filaggrin precursor proteins are localized in keratohyalin granules and processed into individual functional filaggrin molecules during terminal epidermis differentiation. Mutations in fillagrins are associated with ICHTHYOSIS VULGARIS.