Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Patch-Clamp Techniques MeSH Descriptor Data 2025


MeSH Heading
Patch-Clamp Techniques
Tree Number(s)
E05.200.500.905
E05.242.800
Unique ID
D018408
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018408
Annotation
a cytol technique for removing a tiny patch of plasma membrane; NIM
Scope Note
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Entry Term(s)
Patch Clamp Technique
Patch-Clamp Technic
Patch-Clamp Technics
Patch-Clamp Technique
Voltage-Clamp Technic
Voltage-Clamp Technics
Voltage-Clamp Technique
Voltage-Clamp Techniques
Whole-Cell Recording
NLM Classification #
QY 95
Previous Indexing
Electrophysiology (1975-1994)
Ion Channels (1978-1994)
Membrane Potentials (1975-1994)
Public MeSH Note
95
History Note
95
Date Established
1995/01/01
Date of Entry
1994/01/25
Revision Date
2020/05/27
Patch-Clamp Techniques Preferred
Voltage-Clamp Techniques Related
Whole-Cell Recording Narrower
page delivered in 0.154s