MeSH Browser

MeSH Heading: Succinate-CoA Ligases
Tree Number(s): D08.811.464.267.500.600
Unique ID: D013389
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013389
Scope Note: Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and ITP instead of GTP.EC 6.2.1.-.
Entry Term(s): Succinate-CoA Ligase; Succinate-CoA Ligase (GDP-Forming); Succinate-CoA Ligases (ADP-Forming); Succinic Thiokinase; Succinic Thiokinases; Succinyl CoA Synthetase; Succinyl CoA Synthetases; Succinyl Coenzyme A Synthetase; Succinyl Coenzyme A Synthetases
Registry Numbers: EC 6.2.1.-; 0
CAS Type 1 Name: Succinate:CoA ligase (GDP- or ADP-forming)
Previous Indexing: Coenzyme A Synthetases (1973); Succinates (1973)
Public MeSH Note: 98; see SUCCINYL COENZYME A SYNTHETASES 1991-97; see COENZYME A SYNTHETASES 1976-90
History Note: 98(76)
Date Established: 1991/01/01
Date of Entry: 1975/07/25
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0020708
Registry Numbers: EC 6.2.1.-
Scope Note: Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and ITP instead of GTP.EC 6.2.1.-.
Terms: Succinate-CoA Ligases Preferred Term
Term UI T039287
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1976); Succinic Thiokinases
Term UI T039284
Date06/20/1975
LexicalTag NON
ThesaurusID UNK (19XX); Succinyl CoA Synthetases
Term UI T039285
Date05/18/1976
LexicalTag NON
ThesaurusID UNK (19XX); Succinic Thiokinase
Term UI T000999156
Date11/22/2019
LexicalTag NON
ThesaurusID NLM (2021); Succinyl CoA Synthetase
Term UI T000999157
Date11/22/2019
LexicalTag NON
ThesaurusID NLM (2021); Succinyl Coenzyme A Synthetase
Term UI T000999158
Date11/22/2019
LexicalTag NON
ThesaurusID NLM (2021); Succinate-CoA Ligase
Term UI T000999155
Date11/22/2019
LexicalTag NON
ThesaurusID NLM (2021); Succinyl Coenzyme A Synthetases
Term UI T039286
Date11/05/1996
LexicalTag NON
ThesaurusID NLM (1998)

Succinate-CoA Ligases MeSH Descriptor Data 2025