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A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.
Entry Term(s)
Receptors, Toll-Like
Toll-Like Receptor
Registry Numbers
0
NLM Classification #
QW 569
Public MeSH Note
2006; TOLL-LIKE RECEPTOR was indexed under MEMBRANE GLYCOPROTEINS & RECEPTORS, CELL SURFACE 1998-2005
A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.