MeSH Browser

MeSH Heading: Vaccines, DNA
Tree Number(s): D12.776.828.868.228.250; D20.215.894.865.450.250; D23.050.865.450.250
Unique ID: D019444
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019444
Scope Note: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Entry Term(s): DNA Vaccine; DNA Vaccines; Naked DNA Vaccine; Naked DNA Vaccines; Recombinant DNA Vaccine; Recombinant DNA Vaccines; Vaccines, Recombinant DNA
NLM Classification #: QW 805
Previous Indexing: Vaccines, Synthetic (1986-1996)
Public MeSH Note: 97
History Note: 97
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0028927
Scope Note: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Terms: Vaccines, DNA Preferred Term
Term UI T057976
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1997); Recombinant DNA Vaccine
Term UI T000998420
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); DNA Vaccine
Term UI T000998421
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Naked DNA Vaccine
Term UI T000998422
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Recombinant DNA Vaccines
Term UI T057973
Date03/07/1996
LexicalTag NON
ThesaurusID NLM (1997); Vaccines, Recombinant DNA
Term UI T057974
Date03/07/1996
LexicalTag NON
ThesaurusID NLM (1997); DNA Vaccines
Term UI T057975
Date03/05/1996
LexicalTag NON
ThesaurusID NLM (1997); Naked DNA Vaccines
Term UI T057972
Date03/07/1996
LexicalTag NON
ThesaurusID NLM (1997)

Vaccines, DNA MeSH Descriptor Data 2024