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Sorafenib MeSH Descriptor Data 2022


MeSH Heading
Sorafenib
Tree Number(s)
D02.065.950.681.757
D02.455.426.559.389.703.757
D03.066.515.530.750
D03.383.725.547.530.750
Unique ID
D000077157
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077157
Scope Note
A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.
Entry Term(s)
4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxylic acid methyamide-4-methylbenzenesulfonate
BAY 43-9006
BAY 545-9085
BAY-545-9085
BAY-673472
Nexavar
Sorafenib N-Oxide
Sorafenib Tosylate
Pharm Action
Antineoplastic Agents
Protein Kinase Inhibitors
Registry Number
9ZOQ3TZI87
Related Numbers
5T62Q3B36J
5XYK65KIGD
CAS Type 1 Name
2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-
Public MeSH Note
2019; SORAFENIB was indexed under NIACINAMIDE and PHENYLUREA COMPOUNDS 2014-2018, and under BENZENESULFONATES and PYRIDINES 2003-2013
History Note
2019 (2003)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2020/05/27
Sorafenib Preferred
Nexavar Narrower
BAY 43-9006 Narrower
Sorafenib N-Oxide Narrower
BAY-673472 Narrower
BAY 545-9085 Narrower
Sorafenib Tosylate Narrower
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