MeSH Browser

MeSH Supplementary: 1-2-isopropoxy-2-oxidodihydro-4H,6H-spiro(furo(3,2-d)(1,3,2)dioxaphosphinine-7,2'-oxetan)-6-yl)pyrimidine-2,4(1H,3H)-dione
Unique ID: C000620011
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C000620011
Entry Term(s): JNJ-54257099
Pharm Action: Enzyme Inhibitors
Registry Numbers: 0
Heading Mapped to: *Pyrimidinones; *Spiro Compounds
Frequency: 1
Note: a cyclic phosphate ester derivative and 2'-deoxy-2'-spirooxetane uridine nucleotide prodrug which inhibits HCV NS5B RNA-dependent RNA polymerase (RdRp). structure in first source
Source: J Med Chem. 2016 Jun 23;59(12):5790-8
Date of Entry: 2017/06/07
Revision Date: 2017/10/06

1-2-isopropoxy-2-oxidodihydro-4H,6H-spiro(furo(3,2-d)(1,3,2)dioxaphosphinine-7,2'-oxetan)-6-yl)pyrimidine-2,4(1H,3H)-dione MeSH Supplementary Concept Data 2025