MeSH Browser

MeSH Supplementary: R388
Unique ID: C006094
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C006094
Entry Term(s): R 388; R-388; R-factor
Registry Numbers: 0
Heading Mapped to: *Tetrahydrofolate Dehydrogenase
Frequency: 21
Note: drug-resistant form of enzyme, dihydrofolate reductase, biosynthesized by E coli that confers resistance to trimethoprim; increases resistance by 10,000 fold & mediates synthesis of additional dihydrofolate reductase which is 20,000x less susceptible to trimethoprim inhibition; do not confuse with Cat. G heading R FACTORS
Source: Biochem Biophys Res Commun 58(2):412;1974
Date of Entry: 1974/01/01
Revision Date: 2002/04/26

R388 MeSH Supplementary Concept Data 2025