MeSH Browser

MeSH Heading: Tetrahydrofolate Dehydrogenase
Tree Number(s): D08.811.682.662.825
Unique ID: D013762
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013762
Scope Note: An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Entry Term(s): Dihydrofolate Dehydrogenase; Dihydrofolate Reductase; Folic Acid Reductase
CAS Type 1 Name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
Public MeSH Note: 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
Online Note: use TETRAHYDROFOLATE DEHYDROGENASE to search DIHYDROFOLATE DEHYDROGENASE 1966-88
History Note: 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
Entry Combination: antagonists & inhibitors:Folic Acid Antagonists
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30

Entry Combination: antagonists & inhibitors:Folic Acid Antagonists
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0021232
Scope Note: An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Terms: Tetrahydrofolate Dehydrogenase Preferred Term
Term UI T040435
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Dihydrofolate Dehydrogenase
Term UI T040432
Date06/06/1988
LexicalTag NON
ThesaurusID UNK (19XX); Dihydrofolate Reductase
Term UI T040433
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX); Folic Acid Reductase
Term UI T040434
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Tetrahydrofolate Dehydrogenase MeSH Descriptor Data 2024