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Tetrahydrofolate Dehydrogenase MeSH Descriptor Data 2023


MeSH Heading
Tetrahydrofolate Dehydrogenase
Tree Number(s)
D08.811.682.662.825
Unique ID
D013762
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013762
Scope Note
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Entry Term(s)
Dihydrofolate Dehydrogenase
Dihydrofolate Reductase
Folic Acid Reductase
Registry Number
EC 1.5.1.3
CAS Type 1 Name
5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
Public MeSH Note
66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
Online Note
use TETRAHYDROFOLATE DEHYDROGENASE to search DIHYDROFOLATE DEHYDROGENASE 1966-88
History Note
66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
Entry Combination
antagonists & inhibitors:Folic Acid Antagonists
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2005/06/30
Tetrahydrofolate Dehydrogenase Preferred
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