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mu-Crystallins MeSH Descriptor Data 2023


MeSH Heading
mu-Crystallins
Tree Number(s)
D08.811.682.662.436
D12.776.306.366.888
Unique ID
D000090803
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000090803
Scope Note
A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.
Entry Term(s)
CRYM Protein
Crystallin mu
Ketimine Reductase mu-Crystallin
NADP-Regulated Thyroid Hormone Binding Protein
THBP Protein
Registry Number
EC 1.5.1.25
Related Numbers
147681-64-9
Public MeSH Note
2022; for CRYSTALLIN MU see under CRYSTALLINS (1992-2021)
History Note
2022(1992)
Date Established
2022/01/01
Date of Entry
2021/07/09
Revision Date
2021/06/30
mu-Crystallins Preferred
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