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Methylenetetrahydrofolate Dehydrogenase (NADP) MeSH Descriptor Data 2023


MeSH Heading
Methylenetetrahydrofolate Dehydrogenase (NADP)
Tree Number(s)
D08.811.682.662.253
Unique ID
D008754
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D008754
Annotation
do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
Scope Note
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
Entry Term(s)
Methylenetetrahydrofolate Dehydrogenase
Methylenetetrahydrofolate Dehydrogenase (NADP+)
Registry Number
EC 1.5.1.5
CAS Type 1 Name
5,10-Methylenetetrahydrofolate:NADP+ oxidoreductase
Previous Indexing
Oxidoreductases (1973-1974)
Tetrahydrofolates (1973-1974)
See Also
Formate-Tetrahydrofolate Ligase
Methenyltetrahydrofolate Cyclohydrolase
Public MeSH Note
2004; see METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1991-2003; see OXIDOREDUCTASES 1975-1990
History Note
2004(1975);
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2006/07/05
Methylenetetrahydrofolate Dehydrogenase (NADP) Preferred
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