MeSH Browser

MeSH Heading: Formate-Tetrahydrofolate Ligase
Tree Number(s): D08.811.464.259.550
Unique ID: D005574
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005574
Scope Note: A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Entry Term(s): Formyltetrahydrofolate Synthetase; Tetrahydrofolate Formylase
Registry Number: EC 6.3.4.3
Related Numbers: 9023-66-9
CAS Type 1 Name: Formate:tetrahydrofolate ligase (ADP-forming)
Previous Indexing: Formic Acids (1969-1974); Ligases (1969-1974); Tetrahydrofolates (1972-1974)
See Also: Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP)
Public MeSH Note: 98; see FORMYLTETRAHYDROFOLATE SYNTHETASE 1991-97; see LIGASES 1975-90
History Note: 98(75)
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2009/07/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0008774
Registry Number: EC 6.3.4.3
Related Numbers: 9023-66-9
Scope Note: A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Terms: Formate-Tetrahydrofolate Ligase Preferred Term
Term UI T016905
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Formyltetrahydrofolate Synthetase
Term UI T016903
Date11/05/1996
LexicalTag NON
ThesaurusID NLM (1998); Tetrahydrofolate Formylase
Term UI T016904
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Formate-Tetrahydrofolate Ligase MeSH Descriptor Data 2024