NLM Logo

Formate-Tetrahydrofolate Ligase MeSH Descriptor Data 2023


MeSH Heading
Formate-Tetrahydrofolate Ligase
Tree Number(s)
D08.811.464.259.550
Unique ID
D005574
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D005574
Scope Note
A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Entry Term(s)
Formyltetrahydrofolate Synthetase
Tetrahydrofolate Formylase
Registry Number
EC 6.3.4.3
Related Numbers
9023-66-9
CAS Type 1 Name
Formate:tetrahydrofolate ligase (ADP-forming)
Previous Indexing
Formic Acids (1969-1974)
Ligases (1969-1974)
Tetrahydrofolates (1972-1974)
See Also
Methenyltetrahydrofolate Cyclohydrolase
Methylenetetrahydrofolate Dehydrogenase (NADP)
Public MeSH Note
98; see FORMYLTETRAHYDROFOLATE SYNTHETASE 1991-97; see LIGASES 1975-90
History Note
98(75)
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2009/07/10
Formate-Tetrahydrofolate Ligase Preferred
page delivered in 0.154s