MeSH Browser

MeSH Heading: Saccharopine Dehydrogenases
Tree Number(s): D08.811.682.662.750
Unique ID: D012443
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012443
Annotation: /defic: consider also HYPERLYSINEMIAS
Scope Note: Amine oxidoreductases that use either NAD+ (EC 1.5.1.7) or NADP+ (EC 1.5.1.8) as an acceptor to form L-LYSINE or NAD+ (EC 1.5.1.9) or NADP+ (EC 1.5.1.10) as an acceptor to form L-GLUTAMATE. Deficiency of this enzyme causes HYPERLYSINEMIAS.
Entry Term(s): Lysine-2-Oxoglutarate Reductase; Lysine-Ketoglutarate Reductase; Saccharopine Dehydrogenase; Saccharopine Dehydrogenase (NAD+, L-Glutamate Forming); Saccharopine Dehydrogenase (NAD+, L-Lysine Forming); Saccharopine Dehydrogenase (NADP+, L-Glutamate Forming); Saccharopine Dehydrogenase (NADP+, L-Lysine Forming)
Related Numbers: EC 1.5.1.10; EC 1.5.1.7; EC 1.5.1.8; EC 1.5.1.9
Previous Indexing: Ketoglutaric Acids (1972-1974); Lysine (1970-1974); Oxidoreductases (1970-1974)
See Also: Hyperlysinemias
Public MeSH Note: 91; was see under AMINE OXIDOREDUCTASES 1975-90
History Note: 91(75); was see under AMINE OXIDOREDUCTASES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0019332
Related Numbers: EC 1.5.1.10; EC 1.5.1.7; EC 1.5.1.8; EC 1.5.1.9
Scope Note: Amine oxidoreductases that use either NAD+ (EC 1.5.1.7) or NADP+ (EC 1.5.1.8) as an acceptor to form L-LYSINE or NAD+ (EC 1.5.1.9) or NADP+ (EC 1.5.1.10) as an acceptor to form L-GLUTAMATE. Deficiency of this enzyme causes HYPERLYSINEMIAS.
Terms: Saccharopine Dehydrogenases Preferred Term
Term UI T036974
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Saccharopine Dehydrogenase
Term UI T001089431
Date10/06/2020
LexicalTag NON
ThesaurusID NLM (2022); Lysine-Ketoglutarate Reductase
Term UI T036973
Date09/15/1983
LexicalTag NON
ThesaurusID UNK (19XX)

Saccharopine Dehydrogenases MeSH Descriptor Data 2024