MeSH Browser

MeSH Supplementary: tirilazad
Unique ID: C053355
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C053355
Entry Term(s): 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)-triene-3,20-dione monomethane sulfonate; Freedox; U 74006F; U-74006; U-74006F; U74006F; pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16-methyl-, (16alpha)-, monomethanesulfonate; tirilazad mesylate; tirilazad mesylate hydrate
Pharm Action: Antioxidants
Neuroprotective Agents
Registry Numbers: YD064E883I; 0; HXS259UWKW
Related Numbers: 110101-66-1; 110101-67-2; 111793-42-1; HXS259UWKW
Heading Mapped to: *Pregnatrienes
Frequency: 360
Note: a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; structure given in first source; tradename Freedox
Source: J Biol Chem 1987;262(22):10438
Date of Entry: 1987/09/14
Revision Date: 2018/10/15

tirilazad MeSH Supplementary Concept Data 2025