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U 74500A MeSH Supplementary Concept Data 2025


MeSH Supplementary
U 74500A
Unique ID
C053356
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C053356
Entry Term(s)
21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl
21-(4-(5,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl
U 74500E
U-74500A
U-74500E
U74500
U74500A
U74500E
Pharm Action
Anti-Ulcer Agents
Antioxidants
Immunosuppressive Agents
Registry Numbers
IDW4RCM01L
Related Numbers
110101-65-0
CAS Type 1 Name
Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methyl-, hydrochloride, (16alpha)-
Heading Mapped to
*Pregnatrienes
Frequency
81
Note
potent inhibitor of iron-dependent lipid peroxidation; has excellent activity in in vivo models of experimental CNS trauma & ischemia; structure given in first source; RN given is for 3,6-bis(diethylamino) cpd; Cancer Lett 1992;64(1):61-6 uses 5,6-bis(diethylamino) cpd for U 74500A
Source
J Biol Chem 1987;262(22):10438
Date of Entry
1987/09/14
Revision Date
2016/08/17
U 74500A Preferred
21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl Broader
21-(4-(5,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl Broader
U 74500E Related
U74500 Related
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