MeSH Browser

MeSH Supplementary: U 74500A
Unique ID: C053356
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C053356
Entry Term(s): 21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl; 21-(4-(5,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl; U 74500E; U-74500A; U-74500E; U74500; U74500A; U74500E
Pharm Action: Anti-Ulcer Agents
Antioxidants
Immunosuppressive Agents
Registry Numbers: IDW4RCM01L
Related Numbers: 110101-65-0
CAS Type 1 Name: Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methyl-, hydrochloride, (16alpha)-
Heading Mapped to: *Pregnatrienes
Frequency: 81
Note: potent inhibitor of iron-dependent lipid peroxidation; has excellent activity in in vivo models of experimental CNS trauma & ischemia; structure given in first source; RN given is for 3,6-bis(diethylamino) cpd; Cancer Lett 1992;64(1):61-6 uses 5,6-bis(diethylamino) cpd for U 74500A
Source: J Biol Chem 1987;262(22):10438
Date of Entry: 1987/09/14
Revision Date: 2016/08/17

U 74500A MeSH Supplementary Concept Data 2025