A rare chronic inflammatory OBSTRUCTIVE PULMONARY DISEASE that occurs more frequently in persons of East Asian descent. Onset is in adulthood or middle age and is characterized by INFLAMMATION of the BRONCHIOLES, chronic cough, exertional DYSPNEA, and SPUTUM production. Most patients also have chronic paranasal SINUSITIS, Haemophilus influenzae and PSEUDOMONAS AERUGINOSA infections. If untreated, the disorder progresses to BRONCHIECTASIS and RESPIRATORY FAILURE. It has been mapped to a region of chromosome 6. OMIM: 604809