A rare disorder characterized by the precipitation of protein complexes containing FIBRIN; FIBRINOGEN; and FIBRONECTIN as well as IMMUNOGLOBULINS and plasma proteins in the blood upon exposure to cold temperatures. Patients may experience skin symptoms such as RAYNAUD PHENOMENON or PURPURA, as well as systemic effects including THROMBOSIS; transient NEPHROTIC SYNDROME; or HEMATURIA. OMIM: 123540
