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Cyclic neutropenia MeSH Supplementary Concept Data 2024


MeSH Supplementary
Cyclic neutropenia
Unique ID
C536227
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/C536227
Entry Term(s)
Cyclic Hematopoesis
Cyclic Leucopenia
Cyclic hematopoiesis
Neutropenia, cyclic
Periodic Neutropenia
Registry Number
0
Heading Mapped to
*Neutropenia
Frequency
89
Note
A rare form of neutropenia characterized by regular 21-day cyclic fluctuations in the number of blood NEUTROPHILS; MONOCYTES; EOSINOPHILS; LYMPHOCYTES; PLATELETS, and RETICULOCYTES. Patients experience periodic symptoms of FEVER, malaise, mucosal ulcers, and, rarely, life-threatening infections. The disease occurs both as a hereditary autosomal dominant disorder and in an acquired form, with identical phenotypic presentations. Mutations in the ELANE gene have been identified for the inherited form. OMIM: 162800
Date of Entry
2010/08/25
Revision Date
2015/08/18
Cyclic neutropenia Preferred
Cyclic Hematopoesis Narrower
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