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Spherocytosis, Type 1 MeSH Supplementary Concept Data 2025
An autosomal dominant form of hereditary spherocytosis that is characterized by the presence of SPHEROCYTES on the peripheral blood smear. Patients often present with ANEMIA; JAUNDICE and SPLENOMEGALY, resulting in complications that may include CHOLELITHIASIS; HEMOLYSIS, and aplastic crises. Caused by mutations in the ANK1 gene. OMIM: 182900