MeSH Browser

MeSH Supplementary: plecanatide
Unique ID: C584575
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C584575
Entry Term(s): SP-304; Trulance
Pharm Action: Gastrointestinal Agents
Guanylyl Cyclase C Agonists
Registry Numbers: 7IK8Z952OK
CAS Type 1 Name: L-leucine, L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4-12),(7-15)-bis(disulfide)
Heading Mapped to: *Natriuretic Peptides
Frequency: 36
Note: A uroguanylin analog and guanylate cyclase (GC-C receptor) agonist that activates receptors on gut epithelial cells to maintain barrier function, mucus production, and suppress inflammation. It is used in the treatment of chronic idiopathic constipation and other gastrointestinal disorders.
Source: Dig Dis Sci. 2013 Sep;58(9):2580-6.
Indexing Information: Receptors, Guanylate Cyclase-Coupled
Date of Entry: 2013/11/24
Revision Date: 2017/09/29

plecanatide MeSH Supplementary Concept Data 2025